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A healthy, diverse microbiome is fundamental to mucosal integrity it produces the short-chain fatty acids that fuel the gut lining, crowds out pathogenic overgrowths, and maintains the tight junction proteins that regulate intestinal permeability

No published data contradicts these timelines, but no published data specifically validates them either

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The PPAR agonist rosiglitazone can reproduce exercise-evoked endothelial stabilization and BBB integrity, decreasing the levels of inflammatory mediators and oxidative endothelial injury [263]