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The canonical proptosis, a lytic form of cell death, can be elicited by Caspase-1 (which is activated after the binding of the ligands to the inflammasome-forming pattern recognition receptors (PRRs), such as NLRP3 (Shi et al., 2015)) to cleave the pyroptosis executioner, gasdermin D (GSDMD) (Shi et al., 2017)

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