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The cold sensation is especially noticeable in the first 48 weeks of GLP-1 therapy, as your body adjusts to the new hormonal signaling

This is where things often get tricky

The company added that orforglipron is meant to complement, rather than replace Lillys existing portfolio. The drugmaker also said that it is meant to be an easy-to-use oral option with no water or food restrictions. The data readout came three weeks after Lilly said the highest dose of its daily obesity pill helped patients lose almost 12% of their body weight which was less than analyst expectations of 15%

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