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Oxidative cell death in cancer: mechanisms and therapeutic opportunities
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Key manifestations of mitochondrial dysfunction Mitochondrial dysfunction is typically triggered by pathological stresses such as genetic mutations and ischemia, or by the aging process [7], leading to decreased efficiency of the electron transport chain, which in turn causes excessive ROS production and reduced ATP synthesis [8]
doi: 10.4161/cbt.4.10.2184 127 LiHJiaYWangY
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