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It is secreted by enteroendocrine K-cells in the proximal small intestine in response to nutrient intake, particularly fats and carbohydrates
Additionally, inhibiting both FFA1 and GPR119 at the same time does not impact GLP-1 secretion upon chylomicron treatment in primary duodenal cultures (Psichas et al., 2017)
In terms of evidence, insights usually come from three places: randomized trials that catalogue adverse events, real-world observational cohorts that follow patients over time, and pharmacovigilance databases that gather spontaneous reports
They are often used as part of anti-aging treatments
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