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A critical aspect of this involves their interaction with mitochondrial Complex I
The binding of GTP then stimulates adenylyl cyclase, thus increasing intracellular cyclic 3 ,5 -adenosine monophosphate (cAMP)
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276,427 Quantitative systems pharmacology (QSP) models integrate drug mechanisms, pathway dynamics, and patient factors to predict combination therapy outcomes and have progressed to informing clinical trial design
doi: 10.1371/journal.pone.0187082 109 VazquezJGrillitschKDaumGMasATorijaMJBeltranG
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