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Limitations of the model This model was designed to allow us to study various regulatory mechanisms in the transsulfuration pathway and the effects of oxidative stress, particularly as applied to Down syndrome and autism

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Moreover, while some Nrf2 target gene are downregulated upon NAC treatment, NAC can promote the upregulation of Nrf2 itself, subsequently increasing Glut1 expression and glucose uptake in cells lacking Cpt1a (Supplementary Fig

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