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21 :110-112 Key words: diabetes, cardiovascular outcome trial, semaglutide Licensing requirements for new antidiabetic drugs changed in the USA following the rosiglitazone controversy, and between 2008 and 2020 a dedicated randomised controlled cardiovascular outcome trial (CVOT) was usually required either before or after licensing
[19] [20] However, existing NICE guidance on the management of obesity and type 2 diabetes including guidance on approved GLP-1 receptor agonists provides a relevant framework for understanding how such agents are evaluated and monitored within the NHS
While these drugs are typically injected, some patients may desire an alternative method of administering
[12] Gamma knife radiosurgery, a subset of SBRT, is an option for peripheral nerve sheath tumors growing near the brain
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