Aging-related circulating metabolites regulate EC functions Arachidonic acid (AA), a membrane phospholipid component, is metabolized by cyclooxygenases (COXs), lipoxygenases (LOXs), and cytochrome P450 enzymes to generate eicosanoids including prostaglandins (PGs), thromboxanes (TXs), leukotrienes, and epoxyeicosatrienoic acids (EETs) [173, 174]
In aesthetic practice, reducing inflammation is crucial for supporting healing after procedures such as microneedling, laser resurfacing, and chemical peels
These benefits extend far beyond simple moisturization, offering measurable changes in skin structure and function that contribute to a more youthful appearance
The exact human half-life has not been fully confirmed, but current estimates suggest it may remain active for only a few hours