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Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. Small split-face human dermatology studies, usually with fewer than 50 participants per arm, report changes in wrinkle depth and skin density
This method was noted for its pain-free and well-tolerated nature compared to intramuscular (IM) injections (3)
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