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A search of the TGAs database of adverse event notifications for the GLP-1 RA class up to September found there were 72 reports for suicidal ideation, six reports for depressional suicide, four reports of suicide attempt, two reports of completed suicide and one report of self-injurious ideation

Given the established clinical use of GLP-1RAs for the treatment of T2DM, preclinical and clinical research was centered largely around DR, which suggested the neuropathologic protective effects of GLP-1 are due to downregulation of NF-B, proinflammatory cytokines such as TNF-alpha and IL-1beta, and VEGF

Special Considerations for Patients With Existing Kidney Concerns Patients with mild to moderate kidney disease (Stage 23, eGFR 3090) may use tirzepatide with appropriate monitoring and healthcare provider oversight

Boehringer Ingelheim focuses on pharmaceutical research and advanced drug development technologies