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Adequate protein (1.21.6 g/kg body weight) is critical to preserving muscle mass during GLP-1 therapy, especially as appetite suppression reduces overall food intake

132 Transcriptional profiling of liver tissue revealed that PPAR/ deletion downregulated pathways including lipoprotein metabolism and glucose utilization, and upregulated genes connected to innate immunity and inflammation, which collectively correlated with increased plasma glucose and TG