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Patients could lose the same amount or more safely with a comprehensive diet and exercise program
CrAT deficiency leads to accumulating acetyl-CoA, which exerts an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the Krebs cycle
High-fat and spicy foods are particularly notorious for causing stomach upset when combined with GLP-1 medications
Your body does not become "immune" or require higher future doses to compensate
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