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L-arginine is well tolerated at the doses used in research, and reviews of athlete populations found no kidney toxicity at intakes up to 30 g/day in healthy people.[15]Renal Safety of L-Arginine Nutrients (2018) View source The interactions below matter more than the raw dose

Figure 3 Citrullination of arginine residues in myelin basic protein (MBP)and likely other CNS proteins as wellseems to be one important post-translational modification associated with inflammatory demyelination