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Date: November 16, 2025 Source: Cochrane Summary: GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility
93 In contrast, markers of mineral metabolismincluding 25-hydroxyvitamin D, bone-specific alkaline phosphatase (BALP), and PTHremain largely stable over the long term, 94 suggesting that VSG-mediated skeletal remodeling occurs independently of traditional calciumphosphorus regulatory pathways
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