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Zhang TT, Qi XZ, Chen JP, Shi RL, Wen SS, Wang YL, et al

However, the rapid expansion of telehealth has outpaced the development of standardized outcome measurement tools, creating challenges for research synthesis and evidence-based practice

Cell 39 , 1327 (2016)

281 Importantly, while acute or overwhelming endoplasmic reticulum stress can induce cell death, chronic UPR activation favors drug tolerance and persistence, positioning endoplasmic reticulum stress adaptation as a systems-level resistance mechanism complementary to oncogenic signaling network adaptation