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Importantly, rates of gastrointestinal adverse events were similar between groups
36 Five trials (COR-BMOD, 37 NCT02911818, 38 STEP 3, 36 SCALE IBT, 39 and SCALE Insulin trial) 31 specified IBT as a concomitant lifestyle therapy (comprising counselling, dietary advice, and increased physical activity)
Heartburn and constipation: Constipation increases intra-abdominal pressure, which worsens reflux
The Best Oral GLP-1 For Gut Sensitivity In 2026: What To Choose If Nausea, Bloating, Or IBS Flares Up If you're considering an oral GLP-1 because you want the metabolic benefits without injections, but you also have a "sensitive stomach" history (IBS, reflux, nausea-prone, constipation-prone), you're not being picky
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