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In B7H3targeting ADCs armed with a PBD payload that disrupts replication forks, loss-of-function alterations in RB1 and TP53which promote replication stresshave been identified as predictors of therapeutic response 252
They are also expressed in vascular and lymphatic endothelia, affecting proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries 313
doi: 10.62110/sciencein.jist.2024.v12.752 11 GuptaSAgarwalAKrajcirNAlvarezJG
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