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Over the past few years, GLP-1 medications have fundamentally changed how we think about metabolic health

Some include follow-up visits, messaging, and dose adjustments at no additional cost, while others bill for every check-in, even when it is brief or routine

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Given that fluoropyrimidine-based therapy will remain a major treatment modality for patients with advanced CRC for the foreseeable future, the need for better, more effective chemotherapy combinations in biologically selected populations to overcome drug resistance is an urgent, unmet need for patients with CRC worldwide