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It is of note that glioma cells have the ability to express tumor-specific biomarkers on the surface of their cells, as do vascular networks related to glioma cells [93], such as transferrin [94], insulin [95], and glucose transporters (e.g., GLUT-1) [96]
Deleting or inhibiting the Group I mGluRs in rodents is associated with a reduction in learning and memory-associated tasks such as the Morris water maze task, which was the first evidence for the function of mGluR5 receptors in spatial learning using mGluR5 receptor knock-out animals [29]
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