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In OA, the synovial joint lining tissue (synovium) undergoes a fibrotic transformation, with TGF- a key regulator driving an influx of inflammatory immune cells and the activation of resident synovial fibroblasts
These symptoms typically diminish as the body adjusts
In rare cases, more serious side effects can occur which is why medical supervision is essential throughout treatment
Endocrinologia, Diabetes y Nutricion, 71 (3), 124132
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