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Overall, the biochemical mechanisms of COVID-19-induced tissue damage are complex and involve a range of metabolism-disturbing processes, including inflammation, hypoxia, energy deficiency, and accumulation of metabolic intermediates [45]
In addition, a recent study in 384 newly diagnosed patients with type 2 diabetes without a persuasive cushingoid phenotype reported a 5% prevalence of hypercortisolism including 1 patient with a pituitary macroadenoma and 9 patients with an adrenal adenoma (19)
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