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Mechanisms of GLP-1 GLP-1 exerts its effects through multiple mechanisms: Enhancing Insulin Secretion : GLP-1 stimulates the pancreas to release insulin in response to food intake, thereby helping to lower blood glucose levels

The cardiovascular benefits, demonstrated in the SELECT trial showing reduced heart attack and stroke risk with semaglutide, actually argue in favor of continued use for people with cardiovascular risk factors

These therapies are changing diabetes care in ways that extend far beyond traditional glucose control

While many people tolerate GLP-1 medications well, some experience ongoing side effects such as nausea, vomiting, or diarrhoea