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While GLP-1RA continue to be successful 17 , combinatorial approaches are being developed due to the hypothesis that additional pathway engagement will generate greater weight loss, durability of weight loss and improved tolerability 7

GLP-1 receptors are expressed in various tissues, including pancreatic beta cells and the central nervous system [39]

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Considering the documented changes in sensitization and upregulation of TRPV1 in the complete Freunds adjuvant (CFA)-induced inflammatory pain model, CFA was utilized to induce chronic inflammatory pain in mice 43