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The pivotal trials are STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)
10.3390/ph14100979 Pharmaceuticals
You'll need to meet specific eligibility criteria (typically BMI thresholds, age ranges, and health conditions)
By week 24 (six months), patients who've lost 1520% of their starting weight typically see the most pronounced changes: deepened nasolabial folds, visible cheekbone prominence, and temporal hollowing
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