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However, upon immunoblotting for phosphorylated tau at phosphorylation site Thr231, we observed that only CR-fed mice had reduced tau phosphorylation, which reached statistical significance as compared to DL-fed mice (Fig

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The next legally meaningful development will be a documented FDA decision or policy action

That distinction matters if you are dealing with fatigue, insulin resistance, stubborn weight gain, joint pain, elevated CRP, fatty liver, or the low-grade inflammatory state that often travels with metabolic dysfunction