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True synergy emerges when distinct mechanisms converge on shared outcomes through complementary pathways, amplifying net effects beyond what either compound achieves alone
Athletic and high-performance patients usually do weekly during training peaks and monthly during off-cycles
The ESSENCE trial 240-week readout in 2028 will be a landmark, but longer follow-up and adequately powered studies in higher-risk populations (F3-F4 fibrosis) remain priorities
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