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Past infections with hepatitis and frequent alcohol abuse could impair liver function and independently cause depletion of GSH levels ( in vitro research studies in BSL-3 and BSL-2 facilities
Biochemistry 30: 613619 Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R (2004) Glutathione limits Ero1dependent oxidation in the endoplasmic reticulum
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In addition, it is important to acknowledge that the interpretations of the behavioral tests used in preclinical research aimed to test specific traits and phenotypes of complex and multifaceted conditions like depression, anxiety are often debated and poses some challenges
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