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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs
B12 deficiencies often lead to fatigue, weakness, and low stamina
This is why some of those who have had weight loss surgery or surgery to remove part of the stomach have difficulty absorbing the vitamin B12 they need from foods
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