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However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]
and it may increase the risk of hypoglycaemia when used with insulin or sulfonylureas
Diabetes doses go up to 1mg weekly (Ozempic equivalent)
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