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Johns wort can reduce the effectiveness of many prescription medications by speeding up their metabolism (breakdown in the body)
This typically appears within the first few applications and resolves within one to two weeks of continued use
In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]
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