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Specifically, they lost an average of 17.3% of their body weight during treatment and regained about 11.6% after discontinuation
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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death
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