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3,4 Physicians are excited to finally offer a treatment plan other than lifestyle changes 5,6,7 and intravitreal injections of pegcetacoplan (SYFOVRE, Apellis) or avacincaptad pegol (IZERVAY, Astellas Pharma)

This finding laid the groundwork for decades of research (noted in the table below) exploring copper-peptide signaling and its potential biomedical and cosmetic applications

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In addition, PGA and Kyn/Trp may have potential as biomarkers for disease monitoring and risk stratification, although their clinical utility will require validation in independent and longitudinal cohorts