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The BM microenvironment can also play a role in leukemia drug resistance, mediated by a diverse set of mechanisms, both by direct cell adhesion271311 and/or soluble factor release.29282012 In this study, the protective effects of MSC against PTL toxicity were related to decreases in ROS stress and preserved rGSH levels, suggesting that MSC increased the anti-oxidative stress capacity of T-ALL cells and thereby conferred resistance to PTL
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Under physiological conditions, a vast majority of superoxide radical is present in the form of the radical anion (O 2 ), and approximately only 0.6% exists in the protonated form as hydroperoxyl radical HOO (pK a = 4.8)
Carcinoma in the porcelain gallbladder: a relationship revisited
