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The 10 mg dose of tirzepatide showed greater weight reduction versus semaglutide 1 mg by -1.8 mmHg (-3.4 to -0.1) while the 15 mg dose of tirzepatide reduced an additional -3 mmHg (-4.6 to -1.3) compared to semaglutide [65]
However, both medication classes affect the brain and gastrointestinal system, which means indirect interactions are possible
Of note, ChAT neurons at all segments were frequently contacted by GLP-1R axon varicosities (Supplementary Fig
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