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Many age-related changes in circadian rhythms and sleep architecture, such as reduced rhythm amplitude, phase advance, and altered sleep consolidation, may reflect adaptive remodeling of the circadianhomeostatic system rather than intrinsic dysfunction (Scullin and Bliwise, 2015)

Ahmed S, Di Stasi A, Shpall EJ, Khouri IF, Alousi AM, Ciurea SO, Bashir Q, Qazilbash M, Jones RB, Nieto Y, Parmar S, Kebriaei P, Shah N, Rezvani K, Hosing CM, Oran B, Andreeff M , Anderlini P, Andersson BS, Champlin RE, Popat U

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