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More important, the concentration of GLP-1(2836) required for cardioprotection (6 nM) could not possibly be generated by degradation of the 20-fold lower amounts of the parent GLP-1 used in our experiments (0.3 nM)

Indirect mechanisms relate to weight loss, improved glycaemic control, and reduced visceral adiposityall of which independently contribute to lower inflammatory burden

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Here is everything we know about TRIUMPH-1, what we expect from the data, and why this trial matters