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In addition, norfloxacin was shown to increase the activity of metalloproteinase 9 (MMP-9) when administered at various concentrations, whereas sertraline significantly increased the messenger ribonucleic acid (mRNA) levels of matrix metalloproteinase inhibitor-1 (TIMP-1) and disintegrin and metalloproteinase 10 (ADAM-10) at different concentrations

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