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Muscle preservation: Because AOD 9604 targets adipose tissue specifically and does not suppress systemic anabolic signaling, researchers have hypothesized that it may allow for fat loss with less collateral impact on lean mass, though this has not been formally tested in head-to-head trials
Key considerations if a patient discloses combined use include: Gastrointestinal effects : Both agents may independently cause nausea, vomiting, or appetite suppression
While hGH affects glucose tolerance and insulin sensitivity, AOD9604 showed no adverse effects
While higher doses (particularly 54 mg) showed some increase in gastrointestinal-related events, these remained mild to moderate in severity and did not result in treatment discontinuation
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