Studies in lines selectively bred for divergent exercise capacities indicate that low-capacity mice show metabolic abnormalities and mitochondrial impairment, and are more prone to performance fatigability predominantly mediated by peripheral mechanisms (e.g., greater metabolite accumulation and slower metabolic recovery) [3, 4]
Melanotan 2, with broader receptor activity, shows additional effects in studies of appetite regulation, energy balance and sexual stimulation
For those with low strength, further assessment of muscle mass (such as bioelectrical impedance analysis and dual-energy X-ray absorptiometry) is conducted, and the severity is defined by physical manifestations (such as walking speed and the Brief Physical Condition Scale) [2, 3]
Sodhi M, Rezaeianzadeh R, Kezouh A, et al