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Maki, J
That question originated in an Australian university laboratory, was carried into a commercial development program with a stabilized analogue, tested in a series of controlled human trials, and ultimately routed away from drug registration and toward a US dietary-ingredient determination
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PCSK9 is secreted by the liver and it binds to LDL-LDL receptor complexes on hepatocytes which, following endocytosis, stimulates the lysosomal degradation of the LDL receptor (LDLR), thereby reducing the recycling of the LDLR to the plasma membrane
Drug Discovery Today, 28(10), 103714
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