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The NAD + -to-NADH and ATP-to-ADP ratios were calculated from the peak area values of each metabolite within the same individual sample and compared between groups

Molecular dynamics simulations Molecular dynamics simulations have been performed using the AMBER ff19SB force field 57 and the solvent molecules were represented as OPC water molecules 58

In addition to its role in GSH biosynthesis, the -glutamyl cycle also contributes to the degradation of extracellular glutathione and amino acid recycling through the action of membrane-associated -glutamyl transferase (GGT)