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The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
You may experience fatigue or lethargy, among other symptoms, if you have a B12 deficiency
Ethics declarations Conflict of interest SW: advisory boards and honoraria for academic talks from Bausch Health, Eli Lilly, Janssen, and Novo Nordisk
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