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These hormones are rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4)

35 )), improvement in OSAS (SURMOUNT-OSA 43 ) and improvement in MASH 41,42 and heart failure 44,45,46 (for both semaglutide and tirzepatide)), were published over the last year and have markedly moved the field forward, away from weight loss alone

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