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Serious Side Effects and When to Contact a Provider Serious side effects are uncommon, but medical guidance is important if you experience: Severe or persistent abdominal pain Ongoing vomiting Signs of dehydration such as confusion or minimal urination Symptoms of low blood sugar, including shakiness, sweating, or rapid heartbeat Prompt communication with your provider helps prevent complications

In the physiological state, the effect of these incretins is very short-acting, as they are degraded by dipeptidyl peptidase IV

Insulin resistance is a problem because it can lead to various health complications and increase the risk of several chronic diseases