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To the best of our knowledge, such intricate and detailed peptide design rules, including the mapping of the simultaneous activation of three Class B1 GPCRs mediated through biological membranes, have not been reported to date, providing new physiologically relevant, experimentally testable hypotheses and exciting opportunities to guide future polypharmacy drug development
It is worth noting that the current UK Summary of Product Characteristics (SmPC) for Wegovy does not list suicidality as an adverse reaction, although regulatory authorities continue to monitor this area closely
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Nucleic acids research 33 , 68846894, doi:10.1093/nar/gki1000 (2005)
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