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The spore-forming single strain Clostridium butyricum (CBM588) improved progression-free survival and yielded higher response rates when added to nivolumab/ipilimumab in a randomized phase I study of metastatic renal cell carcinoma, and showed a further clinical activity signal when combined with nivolumab plus cabozantinib as first-line therapy, supporting a plausible immunomodulatory contribution of microbiome tuning to ICI outcomes [267, 268]
4 Critical Signs of Glutathione Deficiency 1
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