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These effects may support behavioral change and emotional regulation, potentially bridging pharmacological intervention and long-term psychological improvement

Diffusion tensor imaging studies in migraine without aura have described thalamic microstructural changes between attacks in particular increased fractional anisotropy that varies with time since the last attack and appears to normalise during the attack itself [30] and correlated structuralfunctional alterations of the thalamo-cortical network [31]

The mechanism is likely related to reduced caloric intake and metabolic adjustment rather than a direct drug effect

Women had more polarized views in that they were more likely to both disagree and agree with the idea that naloxone access leads to increased opioid use, with fewer sitting on the fence, while men were more likely to be neutral