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Medications may also play a role, particularly for those with insulin resistance
The AG strategy allows the innovator to capture some of the generic revenue during the exclusivity period and simultaneously splits market share with the first-to-file generic, reducing the value of the 180-day period to the challenger
however using a shared random effect for CL/ F and Q / F and another shared random effect for V c / F and V p / F , assuming a log-normal distribution with correlation between the clearance and volume of distribution parameters
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