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10.1073/pnas.86.5.1461
Although the retro-inverso approach may fail to accurately reproduce biological function in the context of helical structures (e.g., p53 or HIV-1 proteins), certain exceptionssuch as the binding of a p53-derived retro-inverso peptide to its regulator MDM2demonstrate that well-designed D-peptides can, in specific cases, effectively mimic the function of the original peptide
The ubiquinol form is the reduced form, the form that is an electron donor
Findings suggest context-dependent benefits that appear sensitive to formulation and pairing strategies (e.g., hyaluronic acid)
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